Research Program / Claims / imagination-7

The operation of imagination involves mental enzymes, which produce chemical effects at the physical level and can be observed through these chemical effects.

想象力的运作涉及 mental enzymes,这些酶在物理层面产生化学效应,可通过化学效应被观察到。

Concept imagination · Domain Belief Dynamics and Mind–Body Regulation · testable prediction · interface 3/3 · testability 3/3 · status untested · ★ fundable

This program treats the Seth Material as a source of hypotheses, not as doctrine to be validated. Lead dossiers are AI-compiled from the corpus with a book-and-session citation after every statement; literature reviews are AI web-search summaries whose references were all DOI-verified against Crossref; the agenda draft is an AI synthesis. None of it is Seth's original text, and none of it represents scientific consensus. English fields are machine-translated; the Chinese text is authoritative.

Seth sources (book §session)
Adjudicating experiment
One could design: approximately 120 participants in a randomized crossover complete vivid neutral imagery, emotional imagery, difficulty-matched verbal thought, and rest, with at least 48-hour intervals, totaling 2–3 weeks. Saliva is sampled at baseline, immediately post-task, and at 10 and 30 minutes post-task; pre-register α-amylase activity and secretion rate as primary outcomes, while recording salivary flow, heart-rate variability, skin conductance, and respiration, controlling for sampling time, diet, medication, and oral conditions. If peripheral blood enzymology is done, additionally set up an exploratory cohort of about 60 to screen candidate enzymes, then validate in an independent ~200; total project 9–12 months. After detecting relevant changes, one must also identify the molecules, substrates, and catalytic functions before proposing a new enzyme mechanism.
Suggested paper title
Salivary Alpha-Amylase Activity During Vivid Mental Imagery: A Pre-registered Randomized Crossover Study
What it would overturn
Only identifying a new catalytic mechanism that is independent of known autonomic and metabolic pathways and has a causal role in imagination would revise the hypothesis that "imagination-related chemical changes are explained by known physiological pathways."
Candidate labs / funders
Marc J. Weigensberg; Frances A. Maratos; David Sheffield
Specificity of Seth's formulation
"Mental enzymes" lack molecular identity, tissue origin, substrates, reaction direction, or time scale; "having chemical effects" is no more specific than modern physiology.
Note
Addressing Question 1: It is measurable and related experiments exist, but resting control is insufficient to exclude general arousal effects; cortisol is a hormone, not an enzyme, and peripheral enzyme activity cannot directly represent brain enzyme activity.
Evidence (2, DOI-verified via Crossref)

Cite: Future Mind Institute, Seth Material Research Agenda, claim imagination-7, https://www.seth.org.cn/en/research/claims/imagination-7